Development and Evaluation of Valsartan Film Coated Tablets

Valsartan is a FDA approved drug for the treatment of hypertension belongs to a class of drug known as angiotensin II receptor antagonists, which helps to control high blood pressure. Angiotensin II is a substance in the body that increases blood pressure. Valsartan works by blocking the effect of angiotensin II, as a result, blood vessels relaxes and blood pressure is lowered. The aim of the present study is to formulate and evaluate immediate release tablets of Valsartan. Preformulation studies were performed prior to compression. Tablets were formulated by direct compression, wet granulation and slugging techniques. The fabricated tablets were evaluated for various pre compressional parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and post compressional parameters like average weight, thickness, hardness, friability, assay, disintegration time and dissolution studies. Comparatively, slugging technique exhibited the good flow property than direct compression technique. The stability studies were carried out for the optimized batch for six months. The results of the present study showed that among all the formulations, F8 was better in all terms of pre compression and post compression parameters and showed comparably a good dissolution profile with that of the marketed product.